Clinical Trials

Zeroing In on Coffee’s Potential Use Against Neurodegenerative Disease

The health effects of coffee are not a novel field of research. A study in Comprehensive Reviews in Food Science and Food Safety in 2016 determined that the benefits of moderate coffee consumption among adults clearly outweigh its risks, and numerous studies have evaluated its possible neuroprotective effects.


Study: Omalizumab Boosts Safety, Efficacy of Oral Immunotherapy for Multifood Allergies

The immunoglobulin E-blocking drug omalizumab limited the risk of adverse effects associated with oral immunotherapy (OIT) and increased OIT’s overall efficacy in participants with multiple food allergies, a phase 2 clinical trial at Stanford University found.


Ketamine Eyed as Treatment for Depression

Electroconvulsive therapy (ECT) yields remission rates of close to 70 percent for clinically depressed patients who have not responded to antidepressants. However, it can cause side effects, including confusion and retrograde amnesia.


A Cost-effective Approach to Treating Pediatric C-diff

Fecal microbiota transplantation (FMT) via nasogastric feeding tube (NGT) is a cheaper yet similarly effective treatment method for recurrent Clostridium difficile infection (CDI) in children when compared with FMT via colonoscopy or nasoduodenal tube, a study from Children’s Hospital Colorado has found.


Fueling the Debate on Statin Use in Older Adults

The use of statins for primary cardiovascular disease prevention in adults over age 75 is clouded in uncertainty. A recent study in the Journal of the American Geriatrics Society found that statins may significantly lower mortality risk in older adults. That only underscores the need for a large-scale, prospective, randomized clinical trial, researchers say.


Exercise Study Suggests New Approach to Slowing Parkinson’s

High-intensity treadmill exercise can be safely prescribed for patients with de novo Parkinson’s disease (PD) and may slow progression of some of the disease’s effects, according to a phase 2 clinical trial, the results of which were published in JAMA Neurology.


Testosterone Therapy for Older Hypogonadal Men: The Debate Continues

Long-term testosterone therapy improves urinary and sexual function in hypogonadal men, according to a recent study. Other recent findings, however, continue to fuel debate as to whether the potential benefits of the treatment outweigh the risks.


Bunches of Promise: Study Shows Grape Compounds May Prevent Colorectal Cancer

A combination of grape seed extract (GSE) and the grape compound resveratrol suppresses colon cancer stem cells with efficacy similar to that of a chemopreventive drug, but without the latter’s adverse effects, according to Pennsylvania State University researchers. They believe their findings could open the door to novel therapies to prevent colorectal cancer.


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Extended Antibiotic Use May Boost Risk of Colorectal Cancer Precursor

Long use of antibiotics is associated with higher risk of colorectal adenoma, according to an observational study in Gut. Adenomas are precursors for most colorectal cancers.

A multi-institutional team of...


Link between ALS, Schizophrenia May Spur New Paths of Research

Amyotrophic lateral sclerosis and schizophrenia share genetic origins, according to recent research published in Nature Communications. That finding has the potential to change how neurological and psychiatric diseases are studied and furthers hopes of curing both conditions.